After thinking about this some more, I’ve come to the conclusion that it wouldn’t work. Maybe with some other book, but not with Molecular Biology of the Cell.
A.J. Jacobs could read 100 pages of the Britannica and then pick 5 interesting entries to write about, add some anecdotes about how he used his new knowledge in his daily life and voilà. That wouldn’t work with a textbook, I’d end up summarizing almost everything because it’s all inter-linked and that’s not something I want to do.
I’ll keep an eye open for another book that could be turned into a book diary, and I’m certain I’ll find a few cool stand-alone parts in Molecular Biology of the Cell that I can write about here, but for now I’m putting this project on ice.